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Christopher A Salvatore Selected Research

Calcitonin Gene-Related Peptide Receptor Antagonists

11/2015Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.
3/2015Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier.
12/2013Localization of CGRP receptor components, CGRP, and receptor binding sites in human and rhesus cerebellar cortex.
5/2012Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine.
5/2011Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
1/2011Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat.
4/2010Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
1/2009Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.
1/2009Calcitonin gene-related peptide receptor antagonists for the treatment of migraine.
2/2008Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
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Christopher A Salvatore Research Topics

Disease

15Migraine Disorders (Migraine)
01/2016 - 10/2006
2Pain (Aches)
05/2012 - 01/2011
1Neurogenic Inflammation
11/2013
1Headache (Headaches)
01/2011
1Neuroblastoma
01/2009

Drug/Important Bio-Agent (IBA)

14Calcitonin Gene-Related Peptide Receptor AntagonistsIBA
11/2015 - 10/2006
12Calcitonin Gene-Related PeptideIBA
01/2016 - 09/2007
5NeuropeptidesIBA
01/2016 - 02/2008
5Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)IBA
11/2013 - 01/2009
2telcagepantIBA
01/2009 - 02/2008
2piperidineIBA
02/2008 - 11/2007
1Oxazolidinones (2 Oxazolidone)IBA
11/2015
1acetamideIBA
04/2010
1indeneIBA
04/2010
1olcegepantIBA
02/2008
1PiperidinesIBA
10/2006
1BenzodiazepinesIBA
10/2006

Therapy/Procedure

1Therapeutics
02/2008